Auburn is a city in Lee County, Alabama, United States. It is the largest city in eastern Alabama with a 2010 population of 53,380. It is a principal city of the Auburn-Opelika Metropolitan Area. The Auburn-Opelika, AL MSA with a population of 135,833, along with the Columbus, GA-AL MSA and Tuskegee, Alabama, comprises the greater Columbus-Auburn-Opelika, GA-AL CSA, a region home to approximately 500,000 residents. Auburn is a college town and is the home of Auburn University.