Anniston is a city in Calhoun County in the state of Alabama. As of the 2000 census, the population of the city is 24,276. According to the 2005 U.S. Census estimates, the city had a population of 23,741. The city is the county seat of Calhoun County and one of two urban centers/principal cities of and included in the Anniston-Oxford Metropolitan Statistical Area. Named The Model City by Atlanta newspaperman Henry W.