Charlotte County is a county located in the U.S. state of Florida. As of 2010, the population was 159,978. In 2005, the population of the MSA was 154,030. The U.S. Census Bureau 2007 estimate for the county was 152,814 http://www. census. gov/popest/counties/tables/CO-EST2007-01-12. csv. Its county seat is Punta Gorda, Florida.