Talbotton is a city in Talbot County, Georgia, United States. The population was 1,019 at the 2000 census. The city is the county seat of Talbot County. Talbotton may be best known in history as the place where the immigrant Straus family got their start in retail sales in the 19th century. Decades later, the family acquired R.H. Macy & Co. in New York and eventually turned it into the famous Macy's chain.