Irvine is a city in and county seat of Estill County, Kentucky, United States. Its population was 2,843 at the 2000 census. It is located on the Kentucky River at the junction of Kentucky Route 52 and Kentucky Route 89. It was built on land once granted to Green Clay. It was founded on January 28, 1812 and named for William Irvine, an early settler and Indian fighter. The town did not incorporate until 1849, and was ransacked on October 13, 1864 by Confederate guerrillas, who burned the jail.