Kalamazoo is a city in the southwest region of the U.S. state of Michigan. It is the county seat of Kalamazoo County. Kalamazoo is located geographically in Western and Southern Michigan. As of the 2010 census, the city had a total population of 74,262. It is the major city of the Kalamazoo-Portage metropolitan area, which has a population of 326,589 as of 2010.