Pontotoc is a city in Pontotoc County, Mississippi, located to the west of the much larger city of Tupelo. The population was 5,625 at the 2010 census. It is the county seat of Pontotoc County. Pontotoc is a Chickasaw word meaning "Land of Hanging Grapes". The famous outlaws Jesse and Frank James and their gang once hid at an old house which was used as a Union Army hospital during the Battle of Harrisburg or Battle of Tupelo.