Pickens, formerly called Pickens Courthouse, is a city in Pickens County, South Carolina, United States. The population was 3,126 at the 2010 census. Pickens changed its classification from a town to a city in 1998, but it was not reported to the Census Bureau until 2001. It is the county seat of Pickens County. It was named after Andrew Pickens (1739–1817), an American revolutionary soldier and US Congressman for South Carolina.